Ondřej Bernatík

SorCS2 controls Wnt signaling homeostasis during neurodevelopment by regulating Ror2 activity and trafficking

This study identifies SorCS2 as a regulator of Wnt signaling homeostasis by controlling Ror2 trafficking and signaling, with implications for neurodevelopment.

From Patient to Tumor Organoid: Culture Protocol Choice Controls Glioblastoma Tumor Architecture and Identity

This study compares fragment-based and dissociation-based protocols for culturing glioblastoma organoids, finding that fragment-based methods better preserve tumor biology and extracellular matrix features.

The Alzheimer's-Associated SORL1 p.Y1816C Variant Impairs APP Sorting, Axonal Trafficking, and Neuronal Activity in iPSC-Derived Brain Models

This study investigates the effects of the SORL1 p.Y1816C variant on neuronal function using iPSC-derived models, showing impaired SORLA maturation, altered APP processing, and disrupted axonal transport and electrophysiology.

Viral Infection Induces Alzheimer's Disease-Related Pathways and Senescence in iPSC-Derived Neuronal Models

This study shows HSV-1 infection induces Aβ clustering and neurodegeneration pathways in iPSC-derived neurons, supporting the pathogen infection hypothesis for Alzheimer's disease.