Author

Callie E. W. Crawford

University of PennsylvaniaORCID 0009-0008-9600-815XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

George M. BurslemiD· 2 shared Brockton Keen· 1 shared Jenna N. BeyeriD· 1 shared Jordi C. J. HintzeniD· 1 shared Mohd. Altaf NajariD· 1 shared Sebastian Dilones· 1 shared Sydney Gordon· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

George M. BurslemORCID

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2 papers

Recent·Most cited

BiochemistryChemBioChemPeer-reviewedJun 24, 2026

Quinazolinone and Phthalazinone Inhibitors of the HDAC6/Ubiquitin Protein-Protein Interaction

Sydney Gordon, Jordi C. J. Hintzen, Sebastian Dilones…·George M. Burslem

The paper identifies and optimizes quinazolinone and phthalazinone inhibitors targeting the HDAC6 ZnF-UBD/ubiquitin interaction, using computational and experimental methods to improve their physicochemical properties and predict binding affinity.

1 citation

machine learning (classical)drug response / drug discovery

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BiochemistrybioRxivPreprintJun 18, 2024

The Interplay of Acetylation and Ubiquitination Controls PRMT1 Homeostasis

Mohd. Altaf Najar, Jenna N. Beyer, Callie E. W. Crawford, George M. Burslem

The paper identifies acetylation at K228 as a regulator of PRMT1 degradation via FBXL17-mediated ubiquitination, independent of transcript levels.

3 citations

humanproteomics

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