Author

Sebastian Dilones

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Assay:proteomics· 1

Frequent Co-Authors

George M. BurslemiD· 2 shared Altaf Mohd· 1 shared Asad MohammadiD· 1 shared Brockton Keen· 1 shared Callie E. W. CrawfordiD· 1 shared Donita C. BradyiD· 1 shared Eric S. WitzeiD· 1 shared Jia-Ying Lloyd LeeiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

George M. BurslemORCID

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Author profile →

2 papers

Recent·Most cited

Quinazolinone and Phthalazinone Inhibitors of the HDAC6/Ubiquitin Protein-Protein Interaction

Sydney Gordon, Jordi C. J. Hintzen, Sebastian Dilones, Brockton Keen, Callie E. W. Crawford, George M. Burslem

The paper identifies and optimizes quinazolinone and phthalazinone inhibitors targeting the HDAC6 ZnF-UBD/ubiquitin interaction, using computational and experimental methods to improve their physicochemical properties and predict binding affinity.

ChemBioChem · Jun 24, 2026Peer-reviewedBiochemistry

A selective S-acyltransferase inhibitor suppresses tumor growth

Jia-Ying Lloyd Lee, Sebastian Dilones, Timothé Maujean, Asad Mohammad, Altaf Mohd, Noam Auslander, Donita C. Brady, George M. Burslem, Eric S. Witze

The paper identifies an inhibitor of S-acyltransferase ZDHHC20 that suppresses Kras mutant lung tumor growth and improves survival.

bioRxiv · Jul 18, 2024 · PreprintCancer Biology