Author
The University of Kansas Cancer CenterORCID 0009-0009-0228-8582Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Spencer H. Thompson, Kaitlin M. DeHart, Matthew A. Schaich, Bret Freudenthal
This study shows XRCC1 enhances DNA polymerase beta's efficiency in locating DNA damage by shifting its search strategy from 3D to 1D diffusion, improving damage recognition.
Kaitlin M. DeHart, Peyton N. Oden, Tyler Weaver…·Bret Freudenthal
This study reveals how APE1 uses a dynamic search mechanism combining 1D and 3D diffusion to efficiently locate and repair AP-sites in DNA.
Kaitlin M. DeHart, Nicole M. Hoitsma, Spencer H. Thompson…·Bret Freudenthal
This study shows that APE1's Asn174 residue stabilizes the AP-site through hydrogen bonding and electrostatic interactions, which are essential for catalytic activity.