Author
University of Kansas Medical CenterORCID 0009-0007-2122-546XUnclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Spencer H. Thompson, Kaitlin M. DeHart, Matthew A. Schaich, Bret Freudenthal
This study shows XRCC1 enhances DNA polymerase beta's efficiency in locating DNA damage by shifting its search strategy from 3D to 1D diffusion, improving damage recognition.
Kaitlin M. DeHart, Nicole M. Hoitsma, Spencer H. Thompson…·Bret Freudenthal
This study shows that APE1's Asn174 residue stabilizes the AP-site through hydrogen bonding and electrostatic interactions, which are essential for catalytic activity.
Tyler Weaver, Benjamin J. Ryan, Spencer H. Thompson…·Bret Freudenthal
This study determines the structural and kinetic mechanism of DNA Polymerase β processing 1-nt gaps in the nucleosome during DNA repair.