Author

Lara Petricca

IRBM

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 4 Organism:human· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Organism:C. elegans· 1

Frequent Co-Authors

Andrea CaricasoleiD· 4 shared Cristina CariuloiD· 3 shared Margherita Verani· 3 shared Paola Martufi· 3 shared Celia DomingueziD· 2 shared Hilal Ahmed LashueliD· 2 shared Ramee Lee· 2 shared Anass ChikiiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersNeuroscience

Andrea CaricasoleORCID

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5 papers

Recent·Most cited

Modulation of huntingtin S421 phosphorylation in a Huntington's disease mouse model and its detection in nonhuman primate cerebrospinal fluid

Margherita Verani, Paola Martufi, Lara Petricca, Andrea Caricasole, Maria Carolina Spiezia, Olof Larsson, Licia Tomei, Valentina Fodale, Ignacio Muñoz-Sanjuán, Thomas Vogt, Celia Dominguez, Elizabeth M. Doherty, Ramee Lee, Cristina Cariulo

The paper develops an ultrasensitive immunoassay to detect S421 phosphorylation of huntingtin in HD models and nonhuman primate CSF, linking it to disease progression and identifying PRKACA as a kinase involved.

bioRxiv · Jul 18, 2025 · PreprintNeuroscience

IKBKB reduces huntingtin aggregation by phosphorylating Serine 13 via a non-canonical IKK pathway

Cristina Cariulo, Paola Martufi, Margherita Verani, Leticia M. Toledo, Ramee Lee, Celia Dominguez, Lara Petricca, Andrea Caricasole

The paper shows IKBKB reduces mutant huntingtin aggregation by phosphorylating S13 via a non-canonical IKK pathway.

Life Science Alliance · Aug 8, 2023Peer-reviewedNeuroscience

Comparative analysis of total alpha-synuclein (αSYN) immunoassays reveals that they do not capture the diversity of modified αSYN proteoforms

Lara Petricca, Nour Chiki, Layane Hanna-El-Daher, Lorène Aeschbach, Ritwik Burai, Erik Stoops, Mohamed-Bilal Fares, Hilal Ahmed Lashuel

The paper compares three commercial alpha-synuclein immunoassays and finds they fail to capture the diversity of modified alpha-synuclein proteoforms.

Journal of Parkinson s Disease · May 3, 2022Peer-reviewedNeuroscience

Dose-dependent and disease-modifying effects of striatal infusion of cholesterol in Huntington's disease

Giulia Birolini, Marta Valenza, Eleonora Di Paolo, Elena Vezzoli, Francesca Talpo, Claudia Maniezzi, Claudio Caccia, Valerio Leoni, Vittoria Dickinson Bocchi, Paola Conforti, Elisa Sogne, Lara Petricca, Cristina Cariulo, Margherita Verani, Andrea Caricasole, , Elena F. Cattaneo

This study shows that striatal cholesterol infusion prevents cognitive decline and improves motor function in HD mice, with dose-dependent benefits and synaptic recovery.

bioRxiv · May 13, 2020 · PreprintNeuroscience

TBK1 regulates autophagic clearance of soluble mutant huntingtin and inhibits aggregation/toxicity in different models of Huntington's disease

Ramanath Narayana Hegde, Anass Chiki, Lara Petricca, Paola Martufi, Nicolas Arbez, Laurent Mouchiroud, Johan H. Auwerx, Christian Landles, Gillian P. Bates, Malvindar K. Singh‐Bains, Maurice A. Curtis, Richard L. M. Faull, Christopher A. Ross, Andrea Caricasole, Hilal Ahmed Lashuel

This study identifies TBK1 as a kinase that phosphorylates mutant huntingtin, reduces its aggregation and toxicity in multiple HD models.

bioRxiv · Dec 10, 2019 · PreprintNeuroscience