Pharmacology & ToxicologybioRxivPreprint
Identification and Characterization of a Small Molecule Ligand for the Huntingtin-HAP40 Complex
Rocher Leung, Esther Wolf, Justin C. Deme…·Rachel Harding
The paper identifies a small molecule ligand for the HTT-HAP40 complex using AS-MS and validates its binding through multiple techniques, highlighting a druggable interface for HD therapeutics.
DOI 10.1101/2025.11.21.689733