Hui Peng

A Metabolic Labeling Strategy for Tracking Protein Synthesis in Complex Biological Systems

This paper introduces TeACAT, a method to track newly synthesized proteins in mice by incorporating a non-canonical amino acid, enabling visualization and quantification with minimal perturbation.

High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds

The paper uses high-throughput affinity-selection mass spectrometry to identify protein targets of ToxCast and PFAS compounds, discovering novel interactions and revealing distinct binding patterns of legacy and replacement PFAS.

A disease-causing Isoleucyl-tRNA synthetase variant leads to altered protein complex formation and cellular stress response

The paper investigates a disease-causing mutation in IARS1 that affects protein complex formation and the integrated stress response, leading to altered cellular stress responses.

Enantioselective Protein Affinity Selection Mass Spectrometry (E-ASMS)

This study introduces E-ASMS, a method to detect weak binders and assess enantioselectivity, identifying 16 binders across 12 human protein targets with confirmed binding mechanisms.

Identification and Characterization of a Small Molecule Ligand for the Huntingtin-HAP40 Complex

The paper identifies a small molecule ligand for the HTT-HAP40 complex using AS-MS and validates its binding through multiple techniques, highlighting a druggable interface for HD therapeutics.

A point mutation in the nuclear speckle protein and splicing factor SRRM2 is associated with amyotrophic lateral sclerosis and causes dysregulation of synapse-associated genes

This study identifies a point mutation in SRRM2 as a risk factor for ALS, showing it disrupts protein interactions and dysregulates synapse-related genes.