Author

Jae Hyun J. Lee

Gladstone InstitutesORCID 0009-0009-2998-5249Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Alexander MarsoniD· 2 shared Brian Rudolph ShyiD· 2 shared Carter ChingiD· 2 shared Julia C. CarnevaleiD· 2 shared Justin EyquemiD· 2 shared Vincent AllainiD· 2 shared Alexis TalbotiD· 1 shared Alvin S. HaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersImmunology

Alexander MarsonORCID

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2 papers

Recent·Most cited

ImmunologyNature BiotechnologyPeer-reviewedAug 17, 2026

Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells

Hyuncheol Jung, Pascal Devant, Carter Ching…·Julia C. Carnevale

This paper develops a virus-like particle-based system for CRISPR gene editing and screening in primary human myeloid cells, identifying TNFAIP3 as a key regulator of inflammatory polarization.

5 citationstop 3%

humanCRISPR screen

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Cancer BiologybioRxivPreprintMay 5, 2026

Development of a Fully Non-Viral 1XX-enhanced BCMA CAR-T Cell Therapy for Multiple Myeloma

Alexis Talbot, K Li, Jae Hyun J. Lee…·Brian Rudolph Shy

This paper develops a non-viral BCMA CAR-T therapy using CRISPR and 1XX signaling, showing improved safety, potency, and persistence in multiple myeloma.

DOI 10.64898/2026.04.20.719660

humangenetic perturbation / CRISPR

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