Tetsuya Takimoto

This study shows TMEM135 deficiency leads to a lipogenic state with increased monounsaturated fatty acids and DHA depletion, which is buffered by peroxisomal metabolism and can be reversed by fish oil.

This study shows that mitochondrial fusion via MFN1 and MFN2 is essential for developing specialized mitochondrial structures and maintaining energy metabolism in rod photoreceptor cells.

The paper introduces PiER, a DNA-based system for functional gene screening that records perturbation-response events without single-cell isolation, and demonstrates its use in identifying WNT-related shRNA candidates.

This paper identifies a novel MYC-GSPT1 feedback loop and reports a dual degrader, GT19630, that effectively targets MYC-driven cancers with anti-proliferative and apoptotic effects.