Gabriele Vilkaite

The paper compares three plasma proteomic metrics across organ systems to assess their associations with brain structure and neurodegenerative disease, finding distinct relationships and modest predictive value.

The paper identifies robust multicellular axes associated with Alzheimer's disease pathology and sex using single-cell data from 427 donors, validated in an independent dataset.

This study shows that RNA-binding deficient TDP-43 mutations in cell models disrupt neuronal differentiation and synaptic pathways, affecting transcriptomic profiles and neurite morphology.