Cancer BiologybioRxivPreprint
Dissecting the TMEM132A-EGFR Dependency to Unlock Translational Therapeutic Opportunities for Pan-Solid Tumor
Yaru Fu, Qiqi Ni, Junhao Wang…·Xijuan Liu
This paper identifies TMEM132A as a pan-cancer target that stabilizes EGFR and drives lipid synthesis, and develops a nanobody to inhibit this interaction, showing antitumor activity in resistant models.
DOI 10.64898/2026.08.30.746586