Author

James W. D. King

Imperial College LondonORCID 0009-0009-7847-6475Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Assay:Hi-C· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:spatial domain detection· 2

Frequent Co-Authors

Matthias MerkenschlageriD· 3 shared Ilinca PatrascaniD· 2 shared Alessandro Carlino· 1 shared Alex MontoyaiD· 1 shared Amanda G. FisheriD· 1 shared Andrew D. Jenkinson· 1 shared Arianna CeccarelliiD· 1 shared Benjamin C. Lehne· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersGenetics

Matthias MerkenschlagerORCID

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4 papers

Recent·Most cited

GeneticsbioRxivPreprintOct 27, 2026

Locus-specific spatial and transcriptional dynamics direct T cell lineage choice in the thymus

Ilinca Patrascan, James W. D. King, Noura Maziak…·Matthias Merkenschlager

The paper investigates how spatial and transcriptional dynamics at Cd4 and Cd8 loci influence T cell lineage choice in the thymus, revealing locus-specific chromatin environments that drive differentiation.

DOI 10.64898/2026.10.26.761611

mousescRNA-seq

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NeurosciencebioRxivPreprintJun 9, 2024

Three-dimensional chromatin mapping of sensory neurons reveals that cohesin-dependent genomic domains are required for axonal regeneration

Ilaria Palmisano, Tong Liu, Wei Gao…·Simone Di Giovanni

This study maps the 3D chromatin architecture of adult sensory neurons and shows cohesin is required for axonal regeneration by organizing genomic domains.

DOI 10.1101/2024.06.09.597974

mouseHi-C

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Molecular BiologybioRxivPreprintFeb 29, 2024

Conserved helical motifs in the Ikaros IDR mediate NuRD interaction and transcriptional repression

Tianyi Zhang, Yi-Fang Wang, Alex Montoya…·Matthias Merkenschlager

This study identifies conserved helical motifs in Ikaros that mediate NuRD interaction and transcriptional repression in pre-B cells and B-ALL.

1 citation

humanproteomics

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Genetic & Genomic MedicineNature CommunicationsPeer-reviewedMay 15, 2023

Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes

Liam McAllan, Damir Baranas̆ić, Sergio Villicaña…·William R. Scott

This study identifies DNA methylation changes associated with extreme obesity and finds causal effects on obesity and metabolic disturbances using Mendelian Randomisation.

44 citationstop 4%

humanDNA methylation

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