James O.S. Hackland

This paper shows that timed WNT pulses can specify distinct neural domains in human pluripotent stem cells, enabling the generation of specific neuron and progenitor types.

The paper benchmarks dopaminergic stem cell models and cell therapy candidates using a human brain atlas to identify off-target populations and lineage plasticity.

This study shows retinoic acid accelerates the generation of enteric neural progenitors from human pluripotent stem cells, which can form enteric neurons and colonize the ENS in mice.

This study shows that varying WNT signal strength in human neural crest formation alters axial identity, with low WNT producing anterior and high WNT producing posterior neural crest cells.

This study identifies that human axial progenitors generate trunk neural crest cells and defines their molecular signatures.