Aaron Zhong

This paper shows that timed WNT pulses can specify distinct neural domains in human pluripotent stem cells, enabling the generation of specific neuron and progenitor types.

The paper benchmarks dopaminergic stem cell models and cell therapy candidates using a human brain atlas to identify off-target populations and lineage plasticity.

The paper identifies pre-established chromatin regions in human ESCs that enable rapid activation of lineage-specific genes during differentiation.

This study uses a knockout village framework to analyze how mutations in diabetes genes alter pancreatic beta cell development, revealing non-canonical cell fate shifts and identifying ISL1 as a key regulator.

This study investigates itaconate's role in human macrophages, showing distinct effects in alveolar-like and M-CSF-derived macrophages during M. tuberculosis infection.

This study develops a CRISPRa-based method to rapidly verify gene editing in human pluripotent stem cells without differentiation.

This paper develops an inducible prime editing system in human pluripotent stem cells that enables efficient and controllable multiplex genome editing.

This study functionally interrogates 20 T2D-associated genes using isogenic hESC-derived β-like cells, identifying variants and genes linked to insulin production and lipotoxicity sensitivity.