Author

J. Ole Klarhof

MRC Laboratory of Molecular BiologyORCID 0009-0009-8140-8131Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Organism:virus· 1

Frequent Co-Authors

Leo C. JamesiD· 2 shared AidanDarian W Douglas· 1 shared Akshay DeshpandeiD· 1 shared Alex B. KleinpeteriD· 1 shared Anna AlbeckaiD· 1 shared Ashwanth Christopher FrancisiD· 1 shared Boglarka VamosiD· 1 shared Christopher AikeniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

Leo C. JamesORCID

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2 papers

Recent·Most cited

MicrobiologyJournal of Molecular BiologyPeer-reviewedJul 17, 2026

The central pore of HIV-1 capsomers promotes sustained stability of the viral capsid

Alex B. Kleinpeter, Donna L. Mallery, Anna Albecka…·Eric O. Freed

This study shows that the central pore of HIV-1 capsomers, mediated by R18 and K25 rings, is critical for capsid stability and post-entry events, with the N21K mutation compensating for R18 loss.

1 citation

virusproteomics

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MicrobiologybioRxivPreprintSep 3, 2025

The host protein cyclophilin A inhibits HIV-1 nuclear entry by decreasing capsid elasticity

Jun Hong, Akshay Deshpande, Yatish Thakare…·Christopher Aiken

This study shows that cyclophilin A inhibits HIV-1 nuclear entry in mutants by reducing capsid elasticity, which is reversed by suppressor mutations.

2 citations

humanexperimental assay

𝕏 PostBluesky