The host protein cyclophilin A inhibits HIV-1 nuclear entry by decreasing capsid elasticity
Jun Hong, Akshay Deshpande, Yatish Thakare, Lora Simonovsky, AidanDarian W Douglas, Conall Mc Guinness, Noa Rotem‐Dai, Michelle Kortyna, J. Ole Klarhof, Jiong Shi, Till Böcking, Leo C. James, Ashwanth Christopher Francis, Itay Y. Rousso, Christopher Aiken
This study shows that cyclophilin A inhibits HIV-1 nuclear entry in mutants by reducing capsid elasticity, which is reversed by suppressor mutations.
bioRxiv · Sep 3, 2025 · PreprintMicrobiology