Author

Amir Ledbetter

Koch Institute for Integrative Cancer Research At MITORCID 0009-0009-8226-0749Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

Ashley A. LemniosiD· 2 shared Darrell J. IrvineiD· 2 shared A Buchanan· 1 shared Agnes A. Walsh· 1 shared Alexander Wang· 1 shared Alice TelesnitskyiD· 1 shared Amber M. Rauch· 1 shared Anna AdelsteiniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

Ashley A. LemniosORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintSep 2, 2026

Atomic layer deposition for core-shell microparticle vaccines enabling programmable antigen delivery and enhanced humoral immune responses

Namit Chaudhary, Holly Coleman, Elias V. Paolone…·Darrell J. Irvine

This study develops ALD-coated microparticles for vaccines that enable controlled antigen release and enhance immune responses against HIV.

DOI 10.64898/2026.05.29.728600

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

Molecular BiologybioRxivPreprintJun 18, 2026

Structural Basis for Dimeric Genome Selection by HIV-1

Nele Merret Hollmann, Siarhei Kharytonchyk, A Buchanan…·Michael F. Summers

This study identifies how dimeric HIV-1 RNA structures facilitate Gag protein assembly, revealing a structural mechanism for genome packaging.

DOI 10.64898/2026.06.17.732839

virusstructural biology

𝕏 PostBluesky

BioengineeringbioRxivPreprintJun 8, 2025

Engineering gene expression dynamics via self-amplifying RNA with drug-responsive non-structural proteins

Parisa Yousefpour, Justin R. Gregory, Kristen Si…·Darrell J. Irvine

This paper designs a drug-regulated gene expression system using self-amplifying RNA with TMP-responsive degradation domains, showing enhanced immune responses in mice.

7 citations

mouseexperimental assay

𝕏 PostBluesky