Ege Ezen

This study identifies SSc synovitis as an IFN-driven stromal condition distinct from RA, with implications for IFNAR1 blockade as a therapeutic strategy.

This paper develops a high-content imaging assay to analyze synovial fibroblasts in arthritis, revealing disease-specific functional heterogeneity and identifying IL-1β as a key driver of autophagy.

This study identifies disease-specific fibroblast-myeloid interactions in RA synovium, showing SPP1 signaling and fibroblast-myeloid-dendritic interactions drive RA inflammation by linking innate immunity to autoimmunity.

The paper shows that HOXD13 regulates gene expression in synovial fibroblasts, influencing primary cilia function and joint-specific RA pathology.