In vivo Proximity & Spatial Proteomics with CRISPR Screening Identify STXBP1 as a Protective Modifier of a-synuclein Toxicity in Dopamine Neurons.
Daichi Shonai, Julie K. Kent, Arinze Emmanuel Okafor, Yudong Gao, Pooja Parameswaran, Edwin Bustamante, Biswarathan Ramani, Yarui Diao, Martin Kampmann, Erik J. Soderblom, Scott H. Soderling
The paper uses in vivo proteomics and CRISPR screening to identify STXBP1 as a protective factor against α-synuclein toxicity in dopamine neurons in Parkinson's disease models.
bioRxiv · Jan 17, 2026 · PreprintNeuroscience