Author
University of PittsburghORCID 0009-0009-9681-6875Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Benjamin R. Duewell, Michael Worcester, Michael J. Chirumbolo…·Scott D. Hansen
This study shows PIP4K inhibits PIP5K lipid kinase activity by disrupting its membrane-mediated dimerization, maintaining PI(4,5)P2 homeostasis.
Michael Worcester, Shayan Nejad, Arya Eimagh Naeini…·Thomas E. Kuhlman
The paper demonstrates that human p38 MAPK selects targets through frequency-dependent biochemical resonance, using oscillating activation states to encode stimuli and activate specific genetic responses.
Victoria L. Holmes, Morgan M.C. Ricci, Claire C. Weckerly…·Gerald R. V. Hammond
The paper shows that single-molecule lipid biosensors reduce inhibition of endogenous effector proteins and improve kinetic fidelity in PI3K signaling studies.