Gerald R. V. Hammond

The paper investigates paralog-specific effects of DGK inhibitors on PA generation during PLC signaling in live cells, finding that BMS-502 inhibits PA production while R59022 paradoxically increases it.

This study compares PI(3,5)P2 biosensors and finds that SnxA is the most sensitive and unbiased tool for detecting this lipid.

This study shows PIP4K inhibits PIP5K lipid kinase activity by disrupting its membrane-mediated dimerization, maintaining PI(4,5)P2 homeostasis.

This study shows that loss of Profilin1 reduces plasma membrane PIP2 levels, linking actin regulation to PIP2 homeostasis and revealing Pfn1's broader role in lipid metabolism.

The paper shows that PI3K signaling lipid production and termination occur exclusively at the plasma membrane, not intracellular membranes.

This study identifies a stereoselective DGK inhibitor that enhances T cell activation and tumor cell cytotoxicity through proteasome-dependent degradation of DGK.

The paper develops PILS-Nir1, a phosphatidic acid biosensor, and shows it detects PA dynamics in live cells with higher sensitivity than existing tools.

The paper shows that single-molecule lipid biosensors reduce inhibition of endogenous effector proteins and improve kinetic fidelity in PI3K signaling studies.