Author

Claire C. Weckerly

University of PittsburghORCID 0000-0003-2368-8429Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 2 Research Focus:protein folding & dynamics· 2 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

Gerald R. V. HammondiD· 5 shared Joshua G. PembertoniD· 2 shared Olivia L. MurtaghiD· 2 shared Tiernan SwayhooveriD· 2 shared 5· 1 shared Adam H. Libby· 1 shared AeRyon KimiD· 1 shared Aizhen Xiao· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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5 shared papersCell Biology

Gerald R. V. HammondORCID

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5 papers

Recent·Most cited

BiochemistryJournal of Biological ChemistryPeer-reviewedSep 7, 2026

Endogenous tracking reveals paralog-specific targets for phosphatidic acid generation during phospholipase C signaling in living cells

Claire C. Weckerly, Olivia L. Murtagh, Tiernan Swayhoover…·Gerald R. V. Hammond

The paper investigates paralog-specific effects of DGK inhibitors on PA generation during PLC signaling in live cells, finding that BMS-502 inhibits PA production while R59022 paradoxically increases it.

DOI 10.1016/j.jbc.2026.113520

humanproteomics

𝕏 PostBluesky

Cell BiologyMolecular Biology of the CellPeer-reviewedAug 5, 2026

Quantitative comparison of PI(3,5)P2 biosensors reveals SnxA is the most sensitive and unbiased

Tiernan Swayhoover, Claire C. Weckerly, Gerald R. V. Hammond

This study compares PI(3,5)P2 biosensors and finds that SnxA is the most sensitive and unbiased tool for detecting this lipid.

DOI 10.1091/mbc.e26-03-0120

proteomicsexperimental assay

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BiochemistrybioRxivPreprintDec 12, 2025

Stereoselective Degradation of Diacylglycerol Kinases Potentiate T cell Activation and Tumor Cell Cytotoxicity

Minhaj Shaikh, Surya Pravo Mookherjee, Claire C. Weckerly…·Ku-Lung Hsu

This study identifies a stereoselective DGK inhibitor that enhances T cell activation and tumor cell cytotoxicity through proteasome-dependent degradation of DGK.

2 citations

humanproteomics

𝕏 PostBluesky

Cell BiologyThe Journal of Cell BiologyPeer-reviewedAug 8, 2025

PILS-Nir1 is a novel phosphatidic acid biosensor that reveals mechanisms of lipid production

Claire C. Weckerly, Taylor A. Rahn, Max Ehrlich…·Gerald R. V. Hammond

The paper develops PILS-Nir1, a phosphatidic acid biosensor, and shows it detects PA dynamics in live cells with higher sensitivity than existing tools.

14 citationstop 4%

humanfluorescence / live-cell microscopy

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Cell BiologyThe Journal of Cell BiologyPeer-reviewedFeb 11, 2025

Single molecule Lipid Biosensors Mitigate Inhibition of Endogenous Effector Proteins

Victoria L. Holmes, Morgan M.C. Ricci, Claire C. Weckerly…·Gerald R. V. Hammond

The paper shows that single-molecule lipid biosensors reduce inhibition of endogenous effector proteins and improve kinetic fidelity in PI3K signaling studies.

8 citations

humanproteomics

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