Jay F. Sarthy

MSstatsBioNet integrates differential proteomics results with biomolecular networks to enable mechanistic interpretation of biological changes.

This study evaluates Aclarubicin's safety and efficacy in pediatric cancer models, finding it effective with reduced genotoxicity and cardiotoxicity compared to doxorubicin.

The paper introduces a high-throughput microplate-based CUT&Tag protocol for parallel processing of 96 samples, achieving comparable quality to benchtop methods.

The paper identifies distinct transcriptional programs in Ewing sarcoma driven by EWS::FLI1 fusions and shows their variability across tumors and cell lines.

The paper shows that G1 phase length regulates H3K27me3 levels in stem and tumor cells, with longer G1 increasing and shorter G1 decreasing H3K27me3.

The paper develops an automated CUT&Tag method to profile chromatin occupancy of KMT2A fusion proteins in leukemia samples, revealing epigenomic heterogeneity and therapeutic sensitivity.

This study shows that H3.1 and H3.3 K27M oncohistones affect chromatin landscapes differently in DMG cells, with H3.1K27M leading to loss of H3K27 trimethylation.

This paper develops scCUT&Tag to profile H3K27me3 in single cells, distinguishing cell types in blood and identifying PcG activity changes in brain tumors before and after treatment.

The paper introduces an automated CUT&RUN platform to profile chromatin modifications in human cell lines and tumor samples, revealing cell-type specific gene regulatory programs.