Author

H. J. Knowles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. E. Grigoriadis· 1 shared A. M. Flanagan· 1 shared A. P. Cribbs· 1 shared A. P. Leite· 1 shared C. Davies· 1 shared F. Amary· 1 shared H.-M. Lee· 1 shared I. Papadimitriou-Olivgeri· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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1 shared paperCancer Biology

A. E. Grigoriadis

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone.

L. Cottone, L. Ligammari, H. J. Knowles, H.-M. Lee, S. Henderson, S. Bianco, C. Davies, S. Strauss, F. Amary, A. P. Leite, R. Tirabosco, K. Haendler, J. L. Schultze, J. Herrero, P. ODonnell, , A. M. Flanagan

This study identifies aberrant paracrine signaling between osteoprogenitors and osteoclasts driven by H3.3 mutations as a mechanism underlying giant cell tumor of bone and its response to treatment.

bioRxiv · Dec 27, 2021Cancer Biology

Loss of mutually protective effects between osteoclasts and chondrocytes in damaged joints drives osteoclast-mediated cartilage degradation via matrix metalloproteinases

Q. C. Larrouture, A. P. Cribbs, S. J. Snelling, H. J. Knowles

This study shows that osteoclasts degrade cartilage via MMPs, and their protective interaction with chondrocytes is lost in damaged joints.

bioRxiv · Jan 3, 2021 · PreprintCell Biology

Osteoblast-osteoclast co-culture amplifies inhibitory effects of FG-4592 on osteoclast formation and reduces bone resorption activity

P. A. Hulley, I. Papadimitriou-Olivgeri, H. J. Knowles

This study shows FG-4592 inhibits osteoclast formation and reduces bone resorption, with osteoblast co-culture enhancing these effects.

bioRxiv · Dec 5, 2019Cell Biology