bioRxivImmunologyPreprint
Bioorthogonal antigens allow the unbiased study of antigen processing and presentation
C. Araman, L. Pieper-Pournara, T. van Leeuwen, A. S. B. Kampstra, T. Bakkum, M. H. S. Marqvorsen, C. Nascimento, W. van der Wulp, M. G. J. M. Groenewold, M. G. M. Camps, H. S. Overkleeft, F. Ossendorp, R. Toes, S. I. van Kasteren
Abstract
Proteolysis is fundamental to many biological processes. In the immune system, it underpins the activation of the adaptive immune response: degradation of antigenic material into short peptides and presentation thereof on major histocompatibility complexes, leads to activation of T-cells. This initiates the adaptive immune response against many pathogens.
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