S. Hernandez-Perez

Spatiotemporal control of microtubule acetylation by mechanical cues regulates lysosome dynamics at the immune synapse of B cells to promote antigen presentation

Proteomic profiling of isolated immune synapses from primary mouse B cells

This study isolates and profiles immune synapses from primary mouse B cells to identify proteins involved in early activation by surface-bound antigens, revealing novel components and pathways.

Loss of Rab8a in B cells leads to increased antibody responses and class-switch recombination

This study shows that Rab8a deficiency in B cells increases antibody responses and class-switch recombination by altering signaling pathways.

BCR-induced protein dynamics and the emerging role of SUMOylation revealed by proximity proteomics

This study uses proximity proteomics to identify dynamic protein changes and SUMOylation events in BCR activation, revealing new roles in signaling pathways.

Missing-In-Metastasis / Metastasis Suppressor 1 modulates B cell receptor signaling, B cell metabolic potential and T cell-independent immune responses.

This study shows that MIM/MTSS1 regulates B cell receptor signaling, metabolic activity, and T cell-independent immune responses, with implications for cancer biology.

B cells rapidly target antigen and surface-derived MHCII into peripheral degradative compartments.

This study identifies specialized early peripheral acidic vesicles (eMIIC) in B cells that facilitate rapid antigen processing and MHCII peptide loading for immune response.