COVID-19 vaccine booster induces a strong CD8+ T cell response against Omicron variant epitopes in HLA-A*02:01+ individuals
A. T. Nguyen, C. Szeto, D. S. M. Chatzileontiadou, Z. W. M. Tong, M. J. Dewar-Oldis, L. Cooper, L. D. Murdolo, K. Y. Chew, K. E. Lineburg, A. Riboldi-Tunicliffe, R. Williamson, B. J. Gardiner, D. Jayasinghe, C. A. Lobos, Y. M. Ahn, E. J. Grant, C. Smith, J. McMahon, K. L. Good-Jacobson, P. J. Barnard, K. R. Short, S. Gras
Abstract
The >30 mutated residues in the Omicron spike protein have led to its rapid classification as a new SARS-CoV-2 variant of concern. As a result, Omicron may escape from the immune system, decreasing the protection provided by COVID-19 vaccines. Preliminary data shows a weaker neutralizing antibody response to Omicron compared to the ancestral SARS-CoV-2 virus, which can be increased after a booster vaccine. Here, we report that CD8+ T cells can recognize Omicron variant epitopes presented by HLA-A*02:01 in both COVID-19 recovered and vaccinated individuals, even 6 months after infection or vaccination. Additionally, the T cell response was stronger for Omicron variant epitopes after the vaccine booster. Altogether, T cells can recognize Omicron variants, especially in vaccinated individuals after the vaccine booster. One-Sentence SummaryCD8+ T cells response against Omicron variant epitopes is stronger after the vaccine booster.
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