K. Y. Chew

Cardiovascular symptoms of PASC are associated with trace-level cytokines that affect the function of human pluripotent stem cell derived cardiomyocytes

This study identifies trace-level cytokines in PASC patients linked to cardiovascular symptoms and shows their impact on cardiomyocyte function using nanotechnology detection.

Oxysterols drive inflammation via GPR183 during influenza virus and SARS-CoV-2 infection

This study identifies oxysterols and GPR183 as drivers of inflammation in the lung during influenza and SARS-CoV-2 infections, showing that targeting GPR183 reduces inflammation and disease severity.

Macrophages only sense infectious SARS-CoV-2 when they express sufficient ACE2 to permit viral entry, where rapid cytokine responses then limit viral replication.

The paper shows that ACE2-expressing macrophages allow SARS-CoV-2 entry and replication, triggering anti-viral responses, while ACE2-negative macrophages do not support viral entry or cytokine release.

COVID-19 vaccine booster induces a strong CD8+ T cell response against Omicron variant epitopes in HLA-A*02:01+ individuals

Pediatric nasal epithelial cells are less permissive to SARS-CoV-2 replication compared to adult cells

The paper compares SARS-CoV-2 replication in pediatric and adult nasal epithelial cells, finding lower viral titers in children for ancestral and Delta variants, but higher replication for Omicron.

Endothelial cells elicit a pro-inflammatory response to SARS-COV-2 without productive viral infection

This study shows that endothelial cells can be infected by SARS-CoV-2 but do not produce infectious virus, instead triggering an inflammatory response through sensing adjacent infections.