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BioinformaticsBioinformaticsPeer-reviewed journal article

DREIMT: a drug repositioning database and prioritization tool for immunomodulation.

Kevin TrouléiD, Hugo López-FernándeziD, Santiago García‐MartíniD, Miguel Reboiro‐JatoiD, Carlos Carretero-PucheiD, Jordi Martorell‐MarugániD, Guillermo Martín‐Serrano, Pedro Carmona‐SáeziD, Daniel Glez‐PeñaiD, Fátima Al‐ShahrouriD, Gonzalo Goméz-LópeziD

PDFDOIPreprint

Abstract

MotivationDrug immunomodulation modifies the response of the immune system and can be therapeutically exploited in pathologies such as cancer and autoimmune diseases. ResultsDREIMT is a new hypothesis-generation web tool which performs drug prioritization analysis for immunomodulation. DREIMT provides significant immunomodulatory drugs targeting up to 70 immune cells subtypes through a curated database that integrates 4,960 drug profiles and ~2,6K immune gene expression signatures. The tool also suggests potential immunomodulatory drugs targeting user-supplied gene expression signatures. Final output includes drug-signature association scores, FDRs and downloadable plots and results tables. Availabilityhttp://www.dreimt.org Contactfalshahrour@cnio.es; ggomez@cnio.es

Citations
17
FWCI
0.99
Field percentile
top 22%

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