bioRxivCancer BiologyPreprint
Killing the enemy or making it your ally? The effects of thiostrepton on tumor associated macrophages
D. A. Pereira-Martins, J. Hilberink, I. Weinhauser, E. Rego, G. Huls, J. J. Schuringa
Abstract
Attempts to convert a tumor supportive M2-polarized macrophage microenvironment into a tumor suppressive M1-polarized one have recently received considerable attention. However, the specificity of novel compounds, their mode-of-action, and efficacy on presumed target cells in vivo needs to be interpreted with caution.
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Modeling Bistable Dynamics Arising from Macrophage-Tumor Interactions in the Tumor Microenvironment
Hwayeon Ryu, Susanna Röblitz, … Anna-Simone Frank·Mathematical BiosciencesPeer-reviewed·Sep 16, 2025
- Stemness overcomes IFNγ-induced antitumour exhaustion in human macrophages
Jessica Nitsche, Clara Jana‐Lui Busch, … Michael H. Sieweke·bioRxiv·Oct 13, 2026
- Polypharmacological Re-programming of Tumor-associated Macrophages Restores Antitumor Immunity
N. Nishida-Aoki, T. S. Gujral·bioRxiv·Apr 10, 2021
- TRAIL promotes the polarization of human macrophages toward a proinflammatory M1 phenotype and is associated with increased survival in cancer patients with high tumor macrophage content
S. Gunalp, D. G. Helvaci, … D. Sag·bioRxiv·Aug 16, 2023
- A stress-NRF2 response axis polarises tumor macrophages and undermines immunotherapy
Dominik J. Schaer, Nadja Schulthess-Lutz, … Florence Vallelian·bioRxiv·Jul 2, 2025
- Multi-scale modeling of macrophage - T cell interactions within the tumor microenvironment and impacts of macrophage-based immunotherapies
Colin G. Cess, Stacey D. Finley·PLoS Computational BiologyPeer-reviewed·Dec 23, 2020