Author

T. S. Gujral

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Organism:mouse· 2

Frequent Co-Authors

A. Folch· 2 shared I. Stepanov· 2 shared N. R. Gottshall· 2 shared R. S. Yeung· 2 shared T. N. Nguyen· 2 shared A. Ahmadianyazdi· 1 shared A. Locke· 1 shared A. M. Ladha· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

A. Folch

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Functional evaluation of microdissected tumor 'cuboids': a microscale ex vivo cancer model that retains a complex tumor microenvironment

L. F. Horowitz, R. A. Rodriguez-Mias, M. Chang, S. Zhu, Y. Tang, A. Locke, N. R. Gottshall, I. Stepanov, C. Stiles, M. Yeung, T. N. Nguyen, E. J. Lockhart, C. Ahls, E. Wayne, W. Wei, , A. Folch

The paper develops a microscale ex vivo cancer model using tumor cuboids that retain a complex tumor microenvironment, enabling drug and immunotherapy testing.

bioRxiv · Mar 22, 2024 · PreprintCancer Biology

Low-Cost Robotic Manipulation of Live Microtissues for Cancer Drug Testing

I. Stepanov, N. R. Gottshall, A. Ahmadianyazdi, D. Sinha, E. Lockhart, T. N. Nguyen, S. Hassan, L. Horowitz, R. Yeung, T. S. Gujral, A. Folch

This paper presents a low-cost robotic platform for manipulating live microtissues to enable cancer drug testing using patient biopsies on 384-well plates.

bioRxiv · Mar 21, 2024Bioengineering

Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib

Y. Pang, Q. Li, Z. Sergi, G. Yu, X. Sang, O. Kim, H. Wang, A. Ranjan, M. Merchant, B. Oudit, R. W. Robey, F. Soheilian, B. Tran, F. J. Nunez, M. Zhang, , J. Wu

This paper identifies zotiraciclib as a therapeutic agent targeting IDH-mutant gliomas by disrupting mitochondrial function and inducing oxidative stress, leading to a clinical trial.

bioRxiv · Jun 29, 2023Cancer Biology

Polypharmacology-based kinome screen identifies new regulators of KSHV reactivation

A. T. Olson, Y. Kang, A. M. Ladha, C. B. Lim, M. Lagunoff, T. S. Gujral, A. P. Geballe

This study identifies kinases regulating KSHV reactivation using a polypharmacology-based screen, revealing both pro-lytic and latency-promoting kinases.

bioRxiv · Feb 1, 2023 · PreprintMicrobiology

Polypharmacological Re-programming of Tumor-associated Macrophages Restores Antitumor Immunity

N. Nishida-Aoki, T. S. Gujral

This study identifies a multi-targeted compound that reprograms tumor-associated macrophages to restore antitumor immunity in mouse models.

bioRxiv · Apr 10, 2021 · PreprintCancer Biology

Kinome-centric pharmacoproteomics identifies signaling pathways underlying cellular responses to targeted cancer drugs

M. Golkowski, H.-T. Lau, M. Chan, H. Kenerson, V. N. Vidadala, A. Shoemaker, D. J. Maly, R. S. Yeung, T. S. Gujral, S.-E. Ong

The paper develops a kinome-centric pharmacoproteomics platform to identify signaling pathways and biomarkers predicting cancer drug responses and resistance in hepatocellular carcinoma.

bioRxiv · Nov 20, 2019Cancer Biology