Michael H. Sieweke

Stemness overcomes IFNγ-induced antitumour exhaustion in human macrophages

This study shows that inducing stemness in human macrophages prevents IFNγ-induced exhaustion, enhancing their antitumour activity and persistence in vivo.

Lipocalin-2-expressing red pulp macrophages link ischemic stroke to systemic immune reprogramming in mice and humans

Splenic Lcn2 is induced biphasically after mouse stroke and localizes to red pulp macrophages; recombinant LCN2 induces T cell and monocyte hyporesponsiveness and monocyte phagocytosis-ROS uncoupling, with human spleen support.

Epromoters bind key stress-related transcription factors to regulate clusters of stress response genes

The paper identifies Epromoters as cis-regulatory elements that regulate clusters of stress-response genes by recruiting key transcription factors, showing their role across different stress models.

Exploring social modulation: Microglia as a key mediator of individual immune response, plasticity and pathology in App-NL-G-F mouse model of Alzheimer's disease

This study investigates how social environment affects Alzheimer's disease progression in App-NL-G-F mice, showing social deficits precede pathology and linking microglia activation to neuroinflammation and neurogenesis.

MAFB drives differentiation by permitting WT1 binding to podocyte 1 specific promoters

The paper identifies MAFB's role in podocyte differentiation by enabling WT1 binding to specific promoters through chromatin accessibility.