Robert C. Wykes

This study shows that focal loss of astrocytic Kir4.1 in the adult hippocampus causes seizures, spreading depolarizations, and postictal impairments.

This paper presents a bidirectional neural interface combining graphene technologies for recording and stimulation, showing that recording performance is not compromised during stimulation.

This paper introduces a microfluidic axialtrode for multimodal neural interfacing, enabling spatially distributed optogenetics, electrophysiological recording, and drug delivery across brain layers.

The paper uses graphene micro-transistor arrays and imaging to study how blood flow and electrical activity change during brain injuries in mice.

This study evaluates flexible graphene-based microelectrodes for deep brain stimulation and recording in Parkinsonian rats, showing high signal quality and potential for adaptive neuromodulation.

The paper investigates ECM remodeling in different epilepsy models and identifies ECM components that predict seizure properties.

This study identifies a novel anticonvulsant compound that targets neuronal homeostasis by increasing Pumilio expression, showing efficacy in Drosophila and mouse seizure models.

This paper introduces flexible graphene micro-transistor depth neural probes for recording infraslow and high-frequency neuronal activity in rodents, demonstrating their utility in epilepsy research.

This study identifies non-APP chromosome 21 genes that influence amyloid-β biology in Down syndrome mouse models, independent of APP copy number.

This paper develops a non-integrating lentiviral gene therapy for refractory focal epilepsy, showing reduced seizure frequency in a rat model.

This paper characterizes a rat model of focal neocortical epilepsy induced by tetanus toxin injection, showing seizure clustering, circadian variation, and predictive seizure counts.

This study shows that focal seizures in mice start as standing waves in V1 and propagate following homotopic connectivity patterns similar to normal visual processing.