Elena R. Rhymes

The neuropathy-causing GARS1{triangleup}ETAQ mutation drives pathology in subsets of motor and sensory neurons in mice

This study shows that the Gars{Delta}ETAQ mutation in mice causes specific peripheral nerve pathology in motor and sensory neurons, affecting multiple functions and providing a model for CMT2D research.

CNTF specifically slows down the axonal transport of signalling endosomes

This study shows that CNTF specifically slows axonal transport of signalling endosomes in both fast and slow motor neurons, highlighting selectivity in NTF regulation of transport.

Processivity and BDNF-dependent modulation of signalling endosome axonal transport are impaired in aged mice

The paper investigates how aging affects signaling endosome transport in motor axons and finds that processivity is impaired, which is not rescued by BDNF treatment due to reduced TrkB receptor expression.

Age-specific and compartment-dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons

This study investigates age-related changes in mitochondrial function and cytoplasmic viscosity in mouse peripheral neurons, finding compartment-specific effects on mitochondrial trafficking and homeostasis.

Boosting BDNF in muscle rescues impaired axonal transport in a mouse model of DI-CMTC peripheral neuropathy

BDNF-dependent modulation of axonal transport is selectively impaired in ALS

This study shows that BDNF-dependent axonal transport is selectively impaired in fast motor neurons of ALS mice, contributing to disease pathology.

Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons

This study shows that blocking the GDNF-RET signalling axis rescues axonal transport deficits in ALS models, suggesting it as a potential therapeutic target.

Genetic dissection of Down syndrome-associated alterations in APP/amyloid-β biology using mouse models

This study identifies non-APP chromosome 21 genes that influence amyloid-β biology in Down syndrome mouse models, independent of APP copy number.