VirusesGenomicsPeer-reviewed journal article
Herpes Simplex Virus Mistyping due to HSV-1 x HSV-2 Interspecies Recombination in Viral Gene Encoding Glycoprotein B
Amanda M. CastoiD, Meei-Li W. HuangiD, Hong Jian XieiD, Keith R. JeromeiD, Anna WaldiD, Christine JohnstoniD, Alexander L. GreningeriD
Abstract
Human herpes simplex viruses (HSV) 1 and 2 are most often typed via molecular assays. Here we describe the first known case of HSV mistyping due to a previously undescribed HSV-1 x HSV-2 recombination event in UL27, the gene that encodes glycoprotein B. This is the first reported HSV interspecies recombination event impacting this gene, which is frequently used as a target for diagnostics and experimental therapeutics.
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