Herpesvirus Infections and Treatments

Distinct labeling of host and viral genomes highlights redistribution of nuclear proteins during HSV-1 infection

The paper uses an adapted anipond technique to identify changes in nuclear protein associations with host and viral genomes during HSV-1 infection, revealing redistribution of key cellular factors.

Interaction with complement factor C1q can contribute to and improve monoclonal antibody-mediated protection against lethal HSV-1 challenge

This study shows that modifying monoclonal antibodies to interact with complement factor C1q can enhance or reduce their ability to protect against lethal HSV-1 infection in neonatal mice.

AAV-Mediated Ribozyme Targeting of HSV-1 Latency-Associated Transcript RNAs Reveals Distinct Functions of the LAT Intron and Exon In Vivo

This study uses ribozymes to target HSV-1 LAT RNA components in vivo, revealing distinct roles of the LAT intron and exon in latency and reactivation.

Modulation of gp130 Cytokine Receptor Family by Herpes Simplex Virus 1 as a Strategy for Immune Evasion?

This study shows HSV-1 downmodulates gp130 cytokine receptors to evade immune responses, impairing antiviral signaling and promoting infection.

Herpes simplex virus pUL56 abolishes neuronal activity by removing voltage-gated ion channels from the plasma membrane

This study identifies HSV-1 protein pUL56 as responsible for removing voltage-gated ion channels from neuronal plasma membranes, disrupting calcium signaling and neuronal activity.

A Tissue-Targeted Immunotherapy Protects Against Recurrent Ocular Herpes Infection and Disease, and Alleviates the Associated Cognitive, Behavioral, and Social Deficits in a 'Humanized' HLA Transgenic Mouse Model of UVB-Induced Reactivation

This paper demonstrates that a PPK immunotherapy reduces HSV-1 reactivation and associated neurobehavioral deficits in a humanized mouse model.

Fixed Nonsynonymous vOka Mutations in IE62 Drive Varicella-Zoster Virus Attenuation in Human Skin

This study identifies specific SNPs in VZV that contribute to vaccine strain attenuation by analyzing their effects on viral growth and skin pathology in human skin organ cultures.

Axonal entry and retrograde transport define HSV-1 latency establishment and reactivation potential in neurons

This study shows that HSV-1 latency and reactivation depend on axonal entry and retrograde transport, with competition among viral particles affecting outcomes.

Effect of HSV-1 ICP0 E3 ubiquitin ligase on CIN85 endosomes

This study shows that HSV-1 ICP0's E3 ubiquitin ligase activity is required for exocytosis of CIN85 endosomes and evasion of antiviral responses.

Tissue-Resident and Effector-Memory Lymphocyte Recruitment to the Ocular Mucosa Requires CCL28/CCR10 Signaling During Recurrent HSV-1 Infection

This study shows that CCL28/CCR10 signaling is essential for recruiting protective lymphocytes to the ocular mucosa during recurrent HSV-1 infection, reducing viral burden and ocular pathology.

Conserved assembly architecture of the essential herpesvirus packaging accessory factor

This study presents cryo-EM structures of herpesvirus packaging accessory factors, revealing conserved pentameric symmetry and a critical positively charged central channel for genome packaging.

Nucleocytoplasmic shuttling of the herpesvirus tegument protein UL47_TEG5 is required for its functional role in horizontal transmission in chickens

This study shows that the nucleocytoplasmic shuttling of MDV UL47_TEG5 is essential for horizontal transmission in chickens, with NES deletions preventing transmission.

Structure-based design of soluble prefusion-stabilized herpes simplex virus type 2 glycoprotein B antigens

This study designs prefusion-stabilized HSV-2 gB antigens using structure-based methods and evaluates their immunogenicity, finding no improvement in neutralizing antibody titers compared to postfusion constructs.

Viral Nuclease Inhibitors: Small molecule disruptors of the UL12 alkaline nuclease display broad anti-herpes virus activity

This paper identifies small molecule inhibitors of herpesvirus alkaline nucleases that show broad antiviral activity against HSV-1 and HCMV.

Virion-wide interactome mapping of HSV-1 reveals maturation-dependent remodeling and convergent organization of herpesvirus tegument networks

This study maps HSV-1 virion-wide protein interactions, revealing maturation-driven network remodeling and conserved organizational principles across herpesviruses.

Structure and mechanism of the HSV-1 origin-binding protein UL9

This study presents cryo-EM structures of HSV-1 UL9 and elucidates its dimerization, origin recognition, and allosteric regulation by ICP8.

HSV-1 hijacks the DNA repair protein RAD51 at gene promoters to drive viral transcription

This study shows HSV-1 uses RAD51 to enhance viral gene expression by binding to promoter regions and interacting with ADNP.

Glycoprotein G enables HSV-2 neuroinvasion and provides protection as a glycosylated vaccine antigen

This study shows that HSV-2 glycoprotein G (mgG-2) is critical for neuroinvasion and that its glycosylation is essential for vaccine efficacy against HSV-2.

Conserved herpesvirus protein kinase (CHPK)-mediated phosphorylation of viral proteins associated with nucleocytoplasmic trafficking during natural infection

This study identifies CHPK-mediated phosphorylation of viral proteins as critical for herpesvirus replication and transmission, revealing its role in regulating nucleocytoplasmic trafficking through post-translational modifications.

Identification of Viral and Cellular Proteins in Proximity to the HSV-2 pUL16 Tegument Protein in Infected Cells

This study identifies cellular and viral proteins interacting with HSV-2 pUL16 in infected human keratinocytes, revealing its functional interactions with pUL21 and PP1.

Calmodulin controls the tempo of HSV-1 gene-expression cascade to reshape infection heterogeneity

This study identifies calmodulin as a host factor that accelerates HSV-1 gene-expression tempo, increasing virus-producing cells and protecting mice from lethal infection.

Six years of clinical herpes simplex virus genotypic acyclovir resistance testing confirms common resistance mechanisms and identifies novel mutations

This paper reviews six years of clinical HSV acyclovir resistance testing, confirming common resistance mechanisms and identifying 23 novel UL23 mutations.

The HSV-1 immediate early protein ICP22 interacts with the human antisense function 1 protein to promote viral replication

This study identifies ICP22 interaction with ASF1 proteins and shows their role in HSV-1 replication and transcription regulation.

Peroxisome dynamics during HSV-1 life cycle in human neurons

This study shows HSV-1 uses peroxisomal metabolism and lipid pathways in human neurons to support its replication and suggests this may contribute to neuronal damage in Alzheimer's disease.

Bioactive Enhanced Adjuvant Chemokine Oligonucleotide Nanoparticles (BEACON) for Mucosal Vaccination Against Genital Herpes

This paper develops BEACON, a mucosal adjuvant that enhances protective immunity against HSV-2 in mice by increasing CD8+ TRM populations and mucosal antibody responses.

Multifaceted regulations of HSV-1 ICP0 on the Anti-Viral Restrictions Imposed by the Host Hippo Kinases Reprogramming

This study investigates how HSV-1 interacts with the host Hippo kinase pathway, showing that viral proteins like ICP0 counteract host defenses by modulating MST1/2 cleavage and apoptosis during infection.

The targeted cytosolic degradation of class I histone deacetylases is essential for efficient alphaherpesvirus replication

This study shows alphaherpesviruses degrade class I HDACs to activate DDR and enhance replication, identifying potential therapeutic targets.

Comparative analysis of varicella-zoster virus and herpes simplex virus 1 interaction with epidermal terminal differentiation in primary human keratinocytes models of differentiation

This study compares how VZV and HSV-1 interact with epidermal differentiation in primary human keratinocytes, showing that viral replication is restricted in differentiated cells, with VZV more affected than HSV-1.

Immunization With Herpes Simplex Virus Nanoparticles Targeting Both Attachment and Fusion Protect Against Infection

This study develops HSV-2 nanoparticles targeting both gD and gH/gL, showing that combined immunization provides robust protection through complementary mechanisms beyond neutralization.

The nuclear egress complex of MHV-68 is not essential for nuclear egress but mediates C-capsid specificity

This study shows that the MHV-68 nuclear egress complex (NEC) is not essential for nuclear egress but mediates C-capsid specificity, allowing some capsids to exit the nucleus through alternative pathways.