Meei-Li W. Huang

Differences in expression of tumor suppressor, innate immune, inflammasome, and potassium/gap junction channel host genes significantly predict viral reservoir size during treated HIV infection

This study identifies host gene expression patterns associated with HIV reservoir size in treated individuals, linking inflammation, innate immunity, and potassium/gap junction channels to viral persistence.

AAV-delivered gene editing for latent genital or orofacial herpes simplex virus infection reduces ganglionic viral load and minimizes subsequent viral shedding in mice

This study shows that AAV-delivered gene editing reduces latent HSV DNA in mice and decreases viral shedding, with some toxicity observed at high doses.

Genome sequencing of 196 Treponema pallidum strains from six continents reveals additional variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar

Host Variation in Type I Interferon Signaling Genes (MX1), CCR5{triangleup}32, and MHC Class I Alleles in Treated HIV+ Non-Controllers Predict Viral Reservoir Size

The paper investigates host genetic variations in MX1, CCR5Δ32, and MHC class I alleles in HIV+ non-controllers on ART and finds associations with HIV reservoir size.

Herpes Simplex Virus Mistyping due to HSV-1 x HSV-2 Interspecies Recombination in Viral Gene Encoding Glycoprotein B

The paper reports a case of HSV mistyping caused by HSV-1 x HSV-2 recombination in the UL27 gene, which is important for diagnostics and therapeutics.

Inherited chromosomally integrated HHV-6 demonstrates tissue-specific RNA expression in vivo that correlates with increased antibody immune response.

This study identifies tissue-specific RNA expression of integrated HHV-6A/B in vivo and links it to increased antibody responses against specific viral antigens.

Prospective real-time metagenomic sequencing during norovirus outbreak reveals discrete transmission clusters

This study uses real-time metagenomic sequencing during a norovirus outbreak to identify transmission clusters and ongoing viral shedding in a hospital setting.

The impact of interspecies recombination on human herpes simplex virus evolution and host immune recognition

This study identifies interspecies recombination events in HSV-2 genomes and shows their impact on genetic variation and T-cell recognition.

RNA sequencing of the in vivo human herpesvirus 6B transcriptome to identify targets for clinical assays distinguishing between latent and active infections

This study uses RNA sequencing to analyze HHV-6B transcriptomes in various samples to identify diagnostic targets distinguishing latent from active infections.

Ultrasensitive capture of human herpes simplex virus genomes directly from clinical samples reveals extraordinarily limited evolution in cell culture

The paper develops tools to directly sequence HSV genomes from clinical samples with high sensitivity and low viral load, revealing limited evolution during cell culture.

Copy number heterogeneity, large origin tandem repeats, and interspecies recombination in HHV-6A and HHV-6B reference strains

The paper uses next-generation sequencing to analyze copy number variations and interspecies recombination in HHV-6A and HHV-6B reference strains, revealing large tandem repeats and a novel recombinant strain.