The AlphaFold Database Ages

Ifigenia Tsitsa; Anja Conev; Alessia David; Suhail A. Islam; Michael J.E. Sternberg

doi:10.1101/2025.06.22.660930

BioinformaticsbioRxivJun 22, 2025

Preprint

The AlphaFold Database Ages

Ifigenia Tsitsa iD, Anja Conev iD, Alessia David iD, Suhail A. Islam iD, Michael J.E. Sternberg iD

Abstract

The AlphaFold database provides 200M protein structures predicted by AlphaFold2 and released in 2022 from sequences in UniProt in April 2021. However, of the 20,504 full-length human structures in the AlphaFold database, 631 entries conflict with UniProt (version 2025_03 i.e. release 3 of 2025 published Jun 18, 2025); and there is a similar discrepancy for other species. This highlights how bioinformatics resources, as exemplified by the AlphaFold database can rapidly age. Time flies in bioinformatics.

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