Oxymatrine Induces Ferroptosis in MKN28 Gastric Cancer Cells

Abstract

This study aimed to investigate the effect and potential mechanism of oxymatrine (OMT) on MKN28 gastric cancercells. Through a series of experiments including CCK8 cell viability assay, lipid peroxidation level detection, and Fe2+ concentration measurement, it was found that OMT significantly inhibited the viability of MKN28 cells in a dose- and time-dependent manner. OMT could induce an increase in intracellular lipid peroxidation level and iron ion concentration, while activating ferroptosis-related signaling pathways, indicating that OMT can induce ferroptosis in MKN28 cells. This study provides a new theoretical basis and potential target for the application of OMT in gastric cancer treatment.