bioRxivCell Biology
Hyperoxia inhibits proliferation of retinal endothelial cells in Myc dependent manner
C. Singh, A. Benos, A. Grenell, S. Rao, B. Anand-Apte, J. Sears
Abstract
Oxygen supplementation is necessary to prevent mortality of severely premature infants. However, the supraphysiological concentration of oxygen utilized in these infants simultaneously creates retinovascular growth attenuation and vasoobliteration that induces retinopathy of prematurity. Here, we report that hyperoxia regulates the cell cycle and retinal endothelial cell proliferation in a previously unknown Myc dependent manner which contributes to oxygen-induced retinopathy.
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Environmental Oxygen Regulates Astrocyte Proliferation to Guide Angiogenesis during Retinal Development
Robin M. Perelli, Matthew L. O’Sullivan, … Jeremy N. Kay·DevelopmentPeer-reviewed·May 1, 2021
- Endothelial Cell Specific Thioredoxin 1-Dependent Signaling in Oxygen-1 Induced Retinopathy
Henry Song, Wenjing Wu, … Faizah N Bhatti·bioRxiv·Nov 6, 2026
- NDUFA4L2 rescues hyperoxia-induced migration defects in retinal endothelial cells by reversing isocitrate dehydrogenase flux blockade
Hyungryun Jang, Ashwin Chandra, … Charandeep Singh·bioRxiv·Jul 15, 2026
- Targeting endothelial ERG to mitigate vascular regression and neuronal ischemia in retinopathies
Eric Ma, Christopher M. Schafer, … Courtney T. Griffin·Proceedings of the National Academy of SciencesPeer-reviewed·Sep 23, 2025
- Neonatal hyperoxia inhibits proliferation of atrial cardiomyocytes by suppressing fatty acid synthesis
Ethan David Cohen, Min Yee, … Michael A. O’Reilly·JCI InsightPeer-reviewed·Jan 28, 2021
- Medium depth influences O2 availability and metabolism in cultured RPE cells
D. T. Hass, Q. Zhang, … J. M. Miller·bioRxiv·Mar 1, 2023