J. M. Miller

Acetyl-CoA carboxylase inhibition increases RPE cell fatty acid oxidation and limits apolipoprotein efflux

This study shows that inhibiting acetyl-CoA carboxylase with Firsocostat increases fatty acid oxidation and reduces lipid deposits in RPE cells, potentially limiting drusen accumulation in AMD.

Whole-genome sequencing confirms multiple species of Galapagos giant tortoises

This paper uses whole-genome sequencing and coalescent methods to show that Galapagos giant tortoises form a species complex with at least 9 species, challenging previous single-species classifications.

Mutagenic-end joining results in smaller deletions in heterochromatin relative to euchromatin

The paper investigates repair mechanisms in Drosophila heterochromatin and euchromatin, finding that heterochromatin favors HR over mutagenic EJ, leading to smaller deletions via SD-MMEJ.

Medium depth influences O2 availability and metabolism in cultured RPE cells

This study shows that medium volume in RPE cell cultures affects O2 availability, altering metabolism and lipid droplet dynamics, and suggests optimal conditions for studying oxidative metabolism in RPE cells.

Lipid Biosynthesis Perturbation Impairs Endoplasmic Reticulum-Associated Degradation

This study shows that lipid biosynthesis perturbation impairs ER-associated degradation in yeast, linking lipid homeostasis to proteostasis.

Identification of Low Population States in Cryo-EM Using Deep Learning

This paper identifies low population states in cryo-EM data using a deep learning classifier, demonstrating its application to a transient state of bacteriophage A511.

Effective strategies for preventing reestablishment of malaria in areas with recent elimination and high transmission potential

This study uses a simulation model to evaluate interventions for preventing malaria reestablishment after elimination in high-transmission areas, finding that high case management and vector control are essential.

PABA Release from Chitosan-PCL with Induced Electric Current

This study quantifies PABA release from chitosan-PCL hydrogels under varying pH and electric current conditions, showing faster release at acidic pH and induced release at basic pH with current.

Light Pollution Increases West Nile Virus Competence in a Ubiquitous Passerine Reservoir Species

This study shows that dim light at night increases the infectiousness of house sparrows to West Nile virus, potentially raising outbreak risk by 41%.

Theory, practice, and conservation in the age of genomics: the Galapagos giant tortoise as a case study

The paper investigates how sampling design affects genetic differentiation estimates in Galapagos giant tortoises using SNP data, finding that structured sampling and proper filtering yield accurate results.