Author

D. T. Hass

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 5 Research Focus:metabolism & bioenergetics· 4 Assay:metabolomics· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. B. Hurley· 7 shared B. M. Robbings· 5 shared C. M. Bisbach· 5 shared M. Sadilek· 4 shared I. R. Sweet· 3 shared A. M. Rountree· 2 shared J. M. Miller· 2 shared K. Pandey· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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7 shared papersBiochemistry

J. B. Hurley

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Author profile →

7 papers

Recent·Most cited

Acetyl-CoA carboxylase inhibition increases RPE cell fatty acid oxidation and limits apolipoprotein efflux

D. T. Hass, K. Pandey, A. L. Engel, N. Horton, B. M. Robbings, R. Lim, M. Sadilek, Q. Zhang, G. A. Autterson, J. M. Miller, J. R. Chao, J. B. Hurley

This study shows that inhibiting acetyl-CoA carboxylase with Firsocostat increases fatty acid oxidation and reduces lipid deposits in RPE cells, potentially limiting drusen accumulation in AMD.

bioRxiv · Nov 7, 2023 · PreprintBiochemistry

In vivo exchange of glucose and lactate between photoreceptors and the retinal pigment epithelium

D. T. Hass, E. Giering, J. Y. S. Han, C. M. Bisbach, K. Pandey, B. M. Robbings, T. O. Mundinger, N. D. Nolan, S. H. Tsang, N. J. Philp, N. S. Peachey, J. B. Hurley

The paper demonstrates that photoreceptors supply lactate to the RPE, supporting a metabolic exchange between these retinal cells.

bioRxiv · Apr 10, 2023 · PreprintBiochemistry

Medium depth influences O2 availability and metabolism in cultured RPE cells

D. T. Hass, Q. Zhang, G. Autterson, R. Bryan, J. B. Hurley, J. M. Miller

This study shows that medium volume in RPE cell cultures affects O2 availability, altering metabolism and lipid droplet dynamics, and suggests optimal conditions for studying oxidative metabolism in RPE cells.

bioRxiv · Mar 1, 2023 · PreprintCell Biology

Monocarboxylate Transporter 1 (MCT1) mediates succinate export in the retina

C. M. Bisbach, D. T. Hass, J. B. Hurley

The paper identifies MCT1 as the transporter mediating succinate export from retinas but finds no MCT-mediated import into RPE.

bioRxiv · Nov 19, 2021Biochemistry

Metabolic function in aging retina and retinal pigment epithelium remains robust despite vision loss

K. A. Tsantilas, W. M. Cleghorn, C. M. Bisbach, J. A. Whitson, D. T. Hass, B. M. Robbings, M. Sadilek, J. D. Linton, A. M. Rountree, A. P. Valencia, M. T. Sweetwyne, M. D. Campbell, H. Zhang, C. S. R. Jankowski, I. R. Sweet, , J. B. Hurley

This study examines metabolic changes in aging mouse retina and eyecup, finding stable glucose and glutamine metabolism despite vision loss.

bioRxiv · Apr 6, 2021Biochemistry

Succinate metabolism uncouples retinal pigment epithelium mitochondria

D. T. Hass, C. M. Bisbach, B. M. Robbings, M. Sadilek, I. R. Sweet, J. B. Hurley

The paper investigates succinate metabolism in retinal pigment epithelium and finds that succinate consumption by eyecup tissue uncouples mitochondrial ATP synthesis from respiration.

bioRxiv · Feb 10, 2021 · PreprintBiochemistry

Succinate can shuttle reducing power from the hypoxic retina to the O2-rich pigment epithelium.

C. M. Bisbach, D. T. Hass, B. M. Robbings, A. M. Rountree, M. Sadilek, I. R. Sweet, J. B. Hurley

The paper shows that succinate shuttles reducing power from the hypoxic retina to the O2-rich pigment epithelium via a malate/succinate cycle.

bioRxiv · Jan 17, 2020Biochemistry