Cell entry inhibitor with sulfonated colloid gold as new potent broad-spectrum virucides

We recently developed nontoxic, broad-spectrum virucidal gold nanoparticles, less than 10nm sized, modified with sulfonic acids (mesilate) that mimic heparan sulfates.Camostat, a serine protease inhibitor can introduce gold nanoparticles to the influenza virus via ionic bonds.In this study, we examined the ability of a novel sulfonated colloid gold to inhibit the virus in vivo. Thus, camostat-colloid gold is a promising candidate for the development of antiviral drugs to prevent and treat influenza infection.