L. E. Brown

Discovery of RNA-Protein Molecular Clamps Using Proteome-Wide Stability Assays

The paper develops a method to discover RNA-protein-small molecule complexes using proteome-wide stability assays and applies it to identify novel DDX helicase targets of rocaglates.

The MYCN 5' UTR as a therapeutic target in neuroblastoma

This study investigates the therapeutic potential of targeting eIF4A1 to inhibit MYCN expression in neuroblastoma by exploiting its role in translation of polypurine-rich 5' UTRs.

A new concept in antiviral drug design yields a potent influenza inhibitor

This paper introduces a new antiviral drug design approach that alters the virion surface microenvironment to block influenza virus entry, showing potent in vitro and in vivo activity.

Self-organized anteroposterior regionalization of early midbrain and hindbrain/spinal cord using micropatterned human pluripotent stem cells

This study demonstrates that micropatterned human pluripotent stem cells self-organize into distinct midbrain and hindbrain/spinal cord regions, revealing a novel regulatory mechanism for AP patterning.

BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking CLU+ CAF expression with HSF1 signaling

This study shows BRCA mutations in pancreatic cancer alter CAF subtypes, specifically increasing CLU+ CAFs, and links this to HSF1 signaling.

The role of gene segment interactions in driving the emergence of dominant gene constellations during influenza virus reassortment

The paper models influenza virus reassortment under antibody pressure, showing that less fit gene constellations can dominate due to higher antigen yields from non-infectious particles or increased hemagglutinin per virion.

Channeling macrophage polarization via selective translation inhibition by rocaglates increases macrophage resistance to Mycobacterium tuberculosis

This study shows rocaglates shift macrophage polarization toward M1-like by inhibiting IL-4 response and enhancing resistance to Mycobacterium tuberculosis.

Condensation tendency of connected contractile tissue with planar isotropic actin network

The paper studies how rat embryonic fibroblast monolayers form radial symmetry under confinement, showing that contractility and cell-cell adhesion drive this structure.

Contextualising UK moorland burning studies: geographical versus potential sponsorship-bias effects on research conclusions

The paper challenges claims of geographical bias in moorland burning studies, arguing that the EMBER project's conclusions are reliable and that sponsorship bias may influence recent research on moorland burning.