Gpnmb Defines a Phagocytic State of Microglia Linked to Neuronal Loss in Prion Disease
Davide Caredio, Giovanni Mariutti, Lisa K. Polzer, Martina Cerisoli, Beatrice Gatta, Yasmine Laimeche, Giulia Miracca, Marc Emmenegger, Marián Hruška-Plocháň, Magdalini Polymenidou, Matthias Schmitz, Inga Zerr, Elena De Cecco, Adriano Aguzzi
The paper identifies Gpnmb as a marker of a phagocytic microglial state linked to neuronal loss in prion disease, showing its role in clearing apoptotic cells.
bioRxiv · Feb 11, 2025 · PreprintNeuroscience