Daisuke Ono

The slow-acting G-protein Gz defines the duration of circadian rest time

This study shows that Gz G-protein regulates the duration of circadian rest time by modulating cAMP-PKA activity and transcriptome remodeling in the SCN.

A preoptic circuit triggers rewarming from torpor

This paper identifies a preoptic circuit involving Crh-expressing neurons that initiates rewarming from torpor in mice and shows similar activation in hibernators.

Diurnality reconfigures circadian network dynamics in the suprachiasmatic nucleus

This study compares SCN network dynamics in diurnal and nocturnal mice, finding species-specific differences in molecular clock rhythms and spatial timing organization.

Chemogenetic activation of astrocytes modulates sleep/wakefulness states in a brain region-dependent manner

This study shows that chemogenetic activation of astrocytes in specific brain regions affects sleep/wakefulness states and cortical oscillations differently.

Dual Orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy

This study shows that ablating both orexin and MCH neurons in mice leads to increased wakefulness, reduced sleep, and more severe cataplexy compared to ablating orexin neurons alone.

Weak Coupling Between Intracellular Feedback Loops Explains Dissociation of Clock Gene Dynamics

The paper shows that weak coupling between feedback loops in circadian clocks leads to dissociated gene expression dynamics at the single-cell level.

GABA neurons in the ventral tegmental area regulate non-rapid eye movement sleep in mice

This study identifies VTAGad67+ GABAergic neurons as key regulators of NREM sleep in mice through chemogenetic and optogenetic manipulations and electrophysiological recordings.