Nicholas A. Clark

This paper shows that kinase inhibitors commonly target multiple kinases, independent of approval status, and highlights the need for better understanding of their polypharmacology.

This study introduces DECIPHAER, a tool that identifies critical mechanisms of tuberculosis drug action by integrating multi-modal data, revealing that respiration inhibition is more impactful than cell wall effects.

The paper introduces a method called Dye Drop for high-throughput single-cell assays in 384-well plates, enabling detailed dose-response analysis of small molecules in breast cancer cell lines.

iLINCS provides a web-based platform for analyzing omics signatures of diseases and cellular perturbations through integrative analytics and visualization tools.

The paper develops a framework to predict signaling pathway activity changes by integrating genetic perturbation data across cell lines, improving prediction accuracy using multi-task learning and supervised methods.

The paper develops a method to predict the mechanism of action of cellular perturbations by analyzing pathway network topology and transcriptional signatures.

The paper develops tools to compare and design optimized small molecule libraries using chemical and biological data, resulting in a more effective kinase inhibitor library.