Florian Nigsch

The transcription factor ZNF469 regulates collagen production in liver fibrosis

The paper identifies ZNF469 as a transcription factor regulating collagen production in liver fibrosis through computational analysis and experimental validation.

Convergence of multiple RNA-silencing pathways on GW182/TNRC6

The paper identifies TRIM71's mechanism of mRNA silencing through recruitment of TNRC6/GW182 and shows competition among silencing pathways.

A novel HERC4-dependent glue degrader targeting STING

This paper identifies AK59 as a molecular glue degrader for STING, showing HERC4 is the key E3 ligase for its degradation and demonstrating efficacy against STING mutations.

Robust and Versatile Arrayed Libraries for Human Genome-Wide CRISPR Activation, Deletion and Silencing

The paper constructs genome-wide CRISPR libraries for gene ablation, activation, and silencing with high efficacy and reports novel gene regulators and modifiers.

Cell types of the human retina and its organoids at single-cell resolution: developmental convergence, transcriptomic identity, and disease map

This study compares cell-type development and transcriptomes in human retinal organoids and adult retinas, finding convergence in transcriptomes and cell-type-specific disease gene expression.

Systematic Chemogenetic Library Assembly

The paper describes the assembly of a chemogenetic library through data mining and crowdsourcing, sharing 4186 compounds with annotated gene targets.

CellSIUS provides sensitive and specific detection of rare cell populations from complex single cell RNA-seq data

The paper benchmarks scRNA-seq methods and introduces CellSIUS, a tool that improves detection of rare cell populations and identifies their functional signatures in human stem cell differentiation.