This study identifies three druggable targets in Plasmodium falciparum gametocytes using high-throughput screening and reveals resistance mechanisms for one compound.

bioRxiv · Sep 13, 2026 · PreprintMolecular Biology

Cell type-focused compound screen in human organoids reveals CK1 and MAPK11 inhibition protects cone photoreceptors from death

Stefan Erich Spirig, Álvaro Herrero-Navarro, Larissa Utz, Valeria J. Arteaga-Moreta, Zoltán Raics, Susana Posada-Céspedes, Stéphanie Chreng, Olaf Galuba, Inga Galuba, Isabelle Claerr, Steffen Renner, Miklos Boldogkoi, Verónica Moreno‐Juan, P. Timo Kleindienst, Adrienn Volak, , Botond Roska

The paper screens 2,707 compounds in human retinal organoids to identify those that protect or damage cone photoreceptors, finding CK1 and MAPK11 inhibitors as protective.

Neuron · Mar 30, 2026Peer-reviewedNeuroscience

Systematic Chemogenetic Library Assembly

Stephen M. Canham, Yuan Wang, Allen Cornett, Douglas S. Auld, Daniel K. Baeschlin, Maude Patoor, Philip R. Skaanderup, Ayako Honda, Luis Llamas, Greg Wendel, Felipa Mapa, Peter Aspesi, Nancy Labbé-Giguère, Gabriel G. Gamber, Daniel S. Palacios, , Jeremy L. Jenkins

The paper describes the assembly of a chemogenetic library through data mining and crowdsourcing, sharing 4186 compounds with annotated gene targets.

Cell chemical biology · Jul 23, 2020Peer-reviewedBioinformatics